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BACKGROUND
Reports are limited regarding clinical and pretreatment features that might predict a pathological complete response (pathCR) after treatment in patients with esophageal cancer (EC). This might allow patient selection for different strategies. This study examines the association of a pathCR with pretreatment variables, overall survival (OS), recurrence‐free survival (RFS), and patterns...
BACKGROUND
Human epidermal growth factor receptor 2 (HER2) mutations have been reported in lung adenocarcinomas. Herein, the authors describe the prevalence, clinical features, and outcomes associated with HER2 mutations in 1007 patients in the Lung Cancer Mutation Consortium (LCMC).
METHODS
Patients with advanced‐stage lung adenocarcinomas were enrolled to the LCMC. Tumor specimens were assessed...
BACKGROUND
Black race is associated with prostate cancer (PC) diagnosis and poor outcome. Previously, the authors reported that black men undergoing radical prostatectomy (RP) in equal‐access hospitals had an increased risk of biochemical disease recurrence (BCR), but recurrences were equally aggressive as those occurring in white men. The authors examined the association between race and long‐term...
BACKGROUND
Obese men are at higher risk of advanced prostate cancer and cancer‐specific mortality; however, the biology underlying this association remains unclear. This study examined gene expression profiles of prostate tissue to identify biological processes differentially expressed by obesity status and lethal prostate cancer.
METHODS
Gene expression profiling was performed on tumor (n = 402)...
BACKGROUND
The role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body radiotherapy (SBRT) has emerged as a novel therapeutic option in pancreatic cancer care. This study evaluated the survival impact of SBRT on patients with unresected pancreatic cancer.
METHODS
The National Cancer Data Base was queried for unresected...
BACKGROUND
Depression screening in patients with cancer is recommended by major clinical guidelines, although the evidence on individual screening tools is limited for this population. Here, the authors assess and compare the diagnostic accuracy of 2 established screening instruments: the depression modules of the 9‐item Patient Health Questionnaire (PHQ‐9) and the Hospital Anxiety and Depression...
Financial burden from cancer treatment is increasingly being recognized as a threat to optimal access, quality, and outcomes of cancer care for patients. Although research in the area is moving at a fast pace, multiple questions remain unanswered, such as how to practically integrate the assessment and management of financial burden into routine health care delivery for patients with cancer. Although...
BACKGROUND
A nocebo is an inert substance associated with adverse events. Although previous studies have examined the positive (placebo) effects of such inert substances, few have examined negative (nocebo) adverse event profiles, particularly in older patients who have higher morbidity and can experience frequent and severe adverse events from cancer therapy.
METHODS
This study focused on placebo/nocebo‐exposed...
BACKGROUND
Patients with recurrent and/or metastatic, radioactive iodine‐refractory thyroid carcinoma have limited treatment options. Sorafenib, an oral kinase inhibitor, is approved by the US Food and Drug Administration for the treatment of radioactive iodine‐refractory thyroid carcinoma, although it demonstrated low response rates (12.2%) as a single agent in the first‐line setting. The objective...
BACKGROUND
Patients with a terminal illness should have access to their chosen location of death. Cancer is the leading cause of non‐accidental death among adolescents and young adults (AYAs; those aged 15‐39 years). Although surveys have suggested that a majority of these patients prefer a home death, to the authors' knowledge, little is known regarding their barriers to accessing their preferred...
BACKGROUND
Existing data supporting the use of proton‐beam therapy (PBT) for limited‐stage small cell lung cancer (LS‐SCLC) are limited to a single 6‐patient case series. This is the first prospective study to evaluate clinical outcomes and toxicities of PBT for LS‐SCLC.
METHODS
This study prospectively analyzed patients with primary, nonrecurrent LS‐SCLC definitively treated with PBT and concurrent...
BACKGROUND
Both the Centers for Medicare and Medicaid Services' (CMS) Hospital Compare star rating and surgical case volume have been publicized as metrics that can help patients to identify high‐quality hospitals for complex care such as cancer surgery. The current study evaluates the relationship between the CMS' star rating, surgical volume, and short‐term outcomes after major cancer surgery....
BACKGROUND
The survivorship needs of patients living with chronic cancer (CC) and their use of survivorship care plans (SCPs) have been overlooked and underappreciated.
METHODS
A convenience sample of 39,088 SCPs completed for cancer survivors with an Internet‐based SCP tool was examined; it included 5847 CC survivors (15%; CC was defined as chronic leukemia and/or recurrent/metastatic cancer of...
BACKGROUND
Colorectal cancer (CRC) screening rates are low among underserved populations. High‐quality patient‐physician communication potentially influences patients' willingness to undergo CRC screening. Community health centers (HCs) provide comprehensive primary health care to underserved populations. This study's objectives were to ascertain national CRC screening rates and to explore the relations...
BACKGROUND
Little is known about opioid prescribing among individuals who have survived cancer. Our aim is to examine a predominantly socio‐economically disadvantaged population for differences in opioid prescribing rates among cancer survivors compared with matched controls without a prior diagnosis of cancer.
METHODS
This was a retrospective population‐wide matched cohort study. Starting in 2010,...
BACKGROUND
Cancer caregiving has been associated with worsening health among caregivers themselves, yet demographic and psychosocial predictors of their long‐term health decline are less known. This study examines changes in caregivers' physical health 2 to 8 years after their family members' cancer diagnosis and prospective predictors of that change.
METHODS
Caregivers (n = 664; mean age, 53.2...
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